They are certainly nice for their overall versatility of finding new sounds and they're fun to play around with... but in terms of sound quality it really sucks the life out of your guitar and amp. I use an effects pedal board with actual effects pedals now... but I still have the PODxt Live.
I'm a Fender guy and I can't imagine playing a digital processor through a '65 Twin Reverb! haha.
In the end though, do what's good for you and your ear. Processors can be fun and they are one of those types of gear that takes a long time to get bored with.