This is just my two cents worth on how I do it. If I hooked up my amps input to output i got a nasty hum. So I got a Bigshot ABY switch , It is really cool hook your guitar to it and then your amps to it and you can switch between them or play them together. I have a Fender 65 twin reverb and a Fender cyber Twin SE that I run together and It will blow your mind at the sounds. I run the twin reverb clean in the center of my music room and the cyber twin is hooked up to 2 marshall 4X12 cabs. I run the cyber twin in stereo mode with the 4X12s on either side of the room for a true stereo sound. I keep the twin reverb clean and then run all my effects through the stereo cyber twin. The combination is wild, and a lot of fun, and no hum I can crank them up full blast and they sound great together..... :) :)