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This song combines both electric and acoustic guitars to great effect, as the tune is mostly synth driven. Brian May's electric tone is well documented and extremely unique sounding, and this song features that in a few spots. Brian made his own guitar that features hand-wound pickups that are somewhere in between humbuckers and single coils. Next in the chain is a home-made treble booster, going into a Vox AC 30 tube amp.

Since his tone falls somewhere between using humbuckers and single coils, a guitar with either would be a close choice. As for the acoustic guitar, choose one that has a bright shimmery tone to add a percussive edge to the rhythm track.

As far as amps go, a Vox AC30 style tube amp is the authentic choice. Crank up the gain to get that distinctive, mid-range distortion Queen is known for.

Also note that there is an acoustic guitar that appears in the bridge section that is actually plugged into an amp for a different tone. Set your amp for a cleaner sound to nail this tone. Check out the settings I used:

Vox AC 30 Model: Drive: 80% Bass: 50% Mid: 75% Treble: 80% Presence: 65