M-Audio makes VERY goood soundcards, but i´d go with the M-
Audio Midiman instead.
As for the software i was always and will always be suggesting Logic Audio Platinum. this proggy is far better than anything else - even if the die hard cubasers say otherwise.
however - what you need will be large Harddrives and ALOT of RAM - 512 mb at minimum!
with that soundcard you wont realy need a mixer because it has 10 inputs and 10 outputs, almost zero latency and a built in mixer.
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