Originally Posted by: sparkyoneonetwoMy whole life I've had rather sweaty hands when doing most stuff. This has become quite an issues while playing because it makes the picks even harder to hold on to and it keeps slipping out as well as I have less control sliding up and down a wet guitar neck. I've though about maybe using talcum powder or something similar to keep my hands dry but don't know if that would affect the guitar at all.

So, is the sweat coming from your actual hands or your wrist and forearm? If it's your wrist and forearm, you could just try sweat bands on your arms, like what drummers wear.