I have a friend with Focal Dystonia, which means that his left hand does not work very well, and it hurts him to do anything with the left side of his body at all, including typing. He has become a left-handed player and has developed a great legato technique to make up for his lagging left hand.

My advice would be to play to your strengths because you can end up being much better than anyone else at one particular thing. Like Django, he only had two fingers so he used all sorts of crazy techniques that played off of his strengths with those fingers, and he invented all sorts of completely awesome stuff because he ended up using his two fingers in ways that nobody ever thought possible.