Hey Keith.

Depends. Are you referring to the 5th fret on the "A" string or the 5th fret on the "B" string?

Fifth fret on the "A" string is a D note.
Fifth fret on the "B" string is an E note.

If, your chords and notes don't sound the same, you might want to check your guitars intonation. Here is a search result at Youtube
http://www.youtube.com/results?search_query=guitar+intonation+setup&aq=1


Here is how you can test your intonation. (This assumes standard tuning E,A,D,G,B,E)

Tune all your open strings to make sure they are in perfect tune.
Then :
Pluck the E strings octave (12th fret) which is an E. It should be in tune with the open E.
Pluck the A strings octave (12th fret) which is an A. It should be in tune with the open A.

Do this for the remaining four strings. If, your open string is in tune but the octave is not, then you have intonation issues and more than likely just needs to have your guitar setup properly. Not very difficult to do.

Again, I'd suggest doing some reading, and or youtube watching. Hope this helps. :)