Most bands go for the scooped mids approach but that's why there aren't a whole lot of unique tones out there. A much better approach is to let eh bass guitar fill in the low end and a touch of the mids, then work on everything above that with your guitar tone. There's no point tweaking a guitar tone that sounds cool by itself because it won't work with the rest of a band. A lot of heavy bands end up with a muddy sound because everyone is playing the same frequencies. Try thinning out the rhythm tone and beefing the bass guitar, then try adding some mids to the lead guitar.