I've got a spider II. I can get some decent tones out of it, but you really have to tweak a lot. The preset channels are atrocious. I really don't know what they were thinking when they made them. For a decent lead tone, I use the "Insane" channel. Turn down the gain to probably 6 or 7. I don't like scooped mids, but whatever floats your boat in that department. I give it a fair amount of mid and treble to give the tone some bite. Add reverb and delay to your preference.
Let your soul shine. Its better than sunshine. Its better than moonshine. Damn sure better than rain.